Pharmacology Animal Studies In animals, amantadine hydrochloride caused several pharmacologic effects at relatively high doses. Signs of motor activity stimulation (increased spontaneous motor activity and antagonism of tetrabenazine- induced sedation) occurred in mice at oral doses of 35-40 mg/kg and above. A transient vasodepressor effect, cardiac arrhythmias and a weak ganglionic-blocking effect in dogs were observed following intravenous doses of 13.5 mg/kg or above. EEG activation has been reported in the rat and rabbit with high parenteral doses. In addition, the observations summarized in the table below have afforded evidence that amantadine HCl causes norepinephrine release and blockade of norepinephrine re-uptake at peripheral autonomic neuron storage sites. Amantadine Response Species Dose (mg/kg) Route Blockade by reserpine pre-treatment of amantadine-induced transient increase in …
[ Continue Reading... ]Active substance / Generic: Robenacoxib Scientific discussion This medicine is approved for use in the European Union The active substance of Onsior is robenacoxib, a non-steroidal anti-inflammatory drug (NSAID) of the coxib class which selectively inhibits the cyclooxygenase 2 enzyme (COX-2). The active substance, robenacoxib is a structural analogue to diclofenac. Onsior is available as tablets in five different strengths (6 mg for cats, and 5 mg, 10 mg, 20 mg and 40 mg for dogs) and as a solution for injection (20 mg/ml for dogs and cats). The benefits of Onsior are its efficacy in the treatment of pain and inflammation in dogs and cats. The most common side effects are gastrointestinal adverse events (vomiting, soft faeces) in cats and dogs; in dogs …
[ Continue Reading... ]Scientific discussion This medicine is approved for use in the European Union Invented name: Equilis Prequenza Te Active substance/INN: A/equine-1/Praque/1/56 ― 100 AU/ml A/equine-2/Newmarket/1/93 ― 50 AU/ml A/equine-2/Newmarket/2/93 ― 50 AU/ml Tetanus Toxoid ― 40 LF/ml (flocculation equivalents) Target species: Horses Therapeutic indication: Active immunisation of horses from 6 months of age against equine influenza to reduce clinical signs and virus excretion after infection, and active immunisation against tetanus to prevent mortality. Wididrawal period: Zero days Pharmaceutical form: Suspension for injection ATCvet code: QI05AL01 Pharmaco-merapeutic group: Equine Influenza and tetanus vaccine Marketing Aumorisation Holder: Intervet International B.V. Wim de Körverstraat 35 NL-5831 AN Boxmeer The Netherlands Equilis Prequenza Te is presented in a 1 ml glass vial or a pre-filled glass syringe. The vaccine contains …
[ Continue Reading... ]Active substance / Generic: Tetanus Toxoid Scientific discussion This medicine is approved for use in the European Union Invented name: Equilis Te Active substance/INN: Tetanus toxoid Target species: Horses Therapeutic indication: Active immunisation of horses from 6 months of age against tetanus to prevent mortality. Withdrawal period: Zero days Pharmaceutical form: Suspension for injection ATCvet code: QI05AB03 Pharmaco-therapeutic group: Tetanus vaccine Marketing Authorisation Holder: Intervet International B.V. Wim de Korverstraat 35 NL-5831 AN Boxmeer The Netherlands Equilis Te is presented in a 1 ml glass vial or a pre-filled glass syringe. The vaccine contains tetanus toxoid. The product is indicated for active immunisation of horses from 6 months of age against tetanus to prevent mortality. The route of administration is intramuscular. Equilis Te: Quality …
[ Continue Reading... ]Scientific discussion This medicine is approved for use in the European Union Invented name: Equilis Prequenza Active substance/INN: A/equine-1/Praque/1/56 ― 100 AU/ml A/equine-2/Newmarket/1/93 ― 50 AU/ml A/equine-2/Newmarket/2/93 ― 50 AU/ml Target species: Horses Therapeutic indication: Active immunisation of horses from 6 months of age against equine influenza to reduce clinical signs and virus excretion after infection. Wididrawal period: Zero days Pharmaceutical form: Suspension for injection ATCvet code: QI05AA01 Pharmaco-merapeutic group: Equine Influenza vaccine Marketing Aumorisation Holder: Intervet International B.V. Wim de Körverstraat 35 NL-5831 AN Boxmeer The Netherlands Equilis Prequenza is presented in a 1 ml glass vial or a pre-lilled glass syringe. The vaccine contains purified haemagglutin subunits (HA) from three different equine influenza virus strains. The product is indicated for …
[ Continue Reading... ]Active substance / Generic: Meloxicam Scientific discussion This medicine is approved for use in the European Union On 9 June 2011, the Committee for Medicinal Products for Veterinary Use (CVMP) adopted a positive opinion, recommending the granting of a marketing authorisation for the veterinary medicinal product Emdocam, a meloxicam 20 mg/ml solution for injection intended for use in cattle, pigs and horses. The applicant for this veterinary medicinal product is Emdoka bvba. The active substance of Emdocam is meloxicam, an anti-inflammatory and anti-rheumatic product, non-steroids (oxicams) ATCvet code: QM01AC06. The benefits of Emdocam are the alleviation of inflammation and relief of pain in the approved indications. The most common side effects are a slight transient swelling at the injection site following subcutaneous administration in …
[ Continue Reading... ]Active substance / Generic: Difloxacin hydrochloride Scientific discussion This medicine is approved for use in the European Union Invented name: Dicural International Non-proprietary Name: Difloxacin hydrochloride Target species (with associated Pharmaceutical form): Chickens (broilers and future breeders): Oral solution Turkeys (young, up to 2kg bodyweight): Oral solution Cattle (calves and young cattle): Solution for injection Dogs: Solution for injection; Coated tablets Therapeutic indications: Chickens and Turkeys: • for treatment of chronic respiratory infections caused by sensitive strains of Escherichia coli and Mycoplasma gallisepticum. Turkeys: • for the treatment of infections caused by Pasteurella multocida. Cattle: • for the treatment of bovine respiratory disease (shipping fever, calf pneumonia) caused by single or mixed infections with Pasteurella haemolytica, Pasteurella multocida, and/or Mycoplasma spp. Dogs: • for …
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