Anticancer Action by Haematopoietic System

By | 2011-06-11

Leukemia

Echinacea (Echinacea Purpurea): Leukemia was induced in 4-week-old female mice predisposed to developing leukemia, and the animals were given powdered Echinacea purpurea leaves orally three times weekly for 8 weeks (7.5mg/mouse/wk). Survival was significantly prolonged and enlargement of thymic lymphoma was significantly suppressed compared with controls. Proliferation of leukemia (MuLV) viruses in the thymus was markedly inhibited as compared with untreated controls after the first oral administration of the E. purpurea preparation. Endogenous IFN-y was also effectively augmented with Echinacea; however, the production of other cytokines such as tumor necrosis factor (TNF)-a and IL-12 was minimal. Thus, suppressive effects on MuLV may depend on enhancement of nonspecific immune or cellular immune systems (or both) by Echinacea (Hayashi, 2001). Daily dietary administration of Echinacea purpurea root extract to normal mice for as little as 1 week also resulted in significant elevations in NK cells (immune cells that are cytolytic to virus-containing cells and many tumor cells). Such boosting of this fundamental immune cell population suggests a prophylactic role for this herb in normal animals (Currier, 2001). Echinacea purpurea -treated mice exhibited a 2.5-fold increase in the absolute numbers of NK cells in their spleens. By 3 months after leukemia induction, E. purpurea-tieated mice still had 2 to 3 times the normal numbers of NK cells in their spleens compared with controls. No leukemic, untreated (control) mice remained alive at 3 months; however, at 3 months after tumor onset, all major hematopoietic and immune cell lineages in the bone marrow birth site were recorded at normal numbers in E. purpurea-consuming, leukemic mice. The survival advantage provided by administration of Echinacea purpurea to these leukemic mice versus untreated mice was highly significant.

Acemannan (Extract Of Aloe Vera): Administration of acemannan for 6 weeks intraperitoneally to clinically symptomatic cats significantly improved both quality of life and survival rate. It was noted that 12 weeks after initiation of treatment, 71% of treated cats were alive and in good health.

Myeloma

Baical Skullcap (Scutellaria baicalensis)

Lymphoma/Lymphosarcoma

Mistletoe (Viscum Album): This extract given as subcutaneous applications (3 times per week for 14 consecutive days; 2, 20, 100, and 500|j,g/injection per mouse) upregulated thymocyte and peripheral blood leukocyte counts in tumor-bearing mice. Tumor weight and tumor volume were reduced with doses greater than 20 μg. Injections protected against metastasis of introduced lymphosarcoma and sarcoma cells. In another study non-Hodgkin’s lymphoma was induced in mice. One group was fed mistletoe-containing diets (10 mg lectin daily); the other group, a control diet. Diet produced several identifiable changes in morphology and size of non-Hodgkin’s lymphoma tumors. In 4 of 15 mice fed the mistletoe-containing diet for 11 days, no evidence of viable tumor was apparent. Results show that this lectin exerts powerful antitumor effects when provided by the oral route.

Cat’s Claw (Uncaria tomentosa)

Gotu Kola (Centella Asiatica, L.): Oral administration of crude extract retarded the development of solid and lymphoma ascites tumor and increased the life span of tumor-bearing mice.

Cordyceps (Cordyceps Sinensis): This extract was given orally to mice implanted with lymphoma cells; it reduced tumor size and prolonged mouse survival time. Mice treated with cyclophosphamide (100 mg/kg) 3 and 5 days after tumor transplantation had their immune suppression restored through treatment.

Turkey Tail Mushroom (Coriolus versicolor)

Bitter Melon (Momordica charantia): Studies have shown activity in various diseases, including numerous cancers (lymphoid leukemia, lymphoma, choriocarcinoma, melanoma, breast cancer, skin tumor, prostatic cancer, squamous carcinoma of tongue and larynx, human bladder carcinoma, and Hodgkin’s disease). Few reports on clinical use in patients with cancer show promising results.

Indian Long Pepper (Piper longum): Alcoholic extract of Piper longum (10 mg/animal) inhibited solid tumor development in mice induced with lymphoma and increased the life span of mice bearing carcinoma to 37.3% and 58.8%, respectively.

Ashwagandha (Wlthania Somnifera): Ethanolic root extract provided a significant increase in life span and a decrease in cancer cell number and tumor weight in lymphoma tumor-induced mice. Hematologic parameters were also corrected by Withania in tumor-bearing mice. Withania somnifera possesses cell cycle disruption and anti-angiogenic activity confirmed in vitro and in vivo, which may be a mediator for its anti-cancer action.

Curcumin (From Curcuma longa): This herb inhibits cell proliferation and induces apoptosis in a dose-dependent manner in vitro in several primary effusion lymohoma cell lines.