Granulamatous Meningoencephalitis

By | 2011-05-28

GME – Granulamatous Meningoencephalitis
/ Peripheral Neuropathies

Definition and cause

Peripheral neuropathies may represent numerous specific diagnoses. Many are inherited and have no successful treatment. When diagnosing such conditions it is helpful to divide them into categories of disease, including degenerative, genetic, idiopathic, inflammatory-noninfectious, inflammatory-infectious, metabolic, neoplasia, trauma, and vascular. Each particular case has a pathophysiology responsible for neurological dysfunction, and this identification may be immensely helpful in selecting proper biological therapy.

Often, the pathophysiology of many of these cases is never fully elucidated and clinicians may be forced to select therapy without a full understanding of the true condition. Common causes are immune-mediated, infectious, secondary to degenerative diseases such as diabetes or cancer, or secondary to a toxic reaction to chemotherapeutics or chemical toxins.

Establishing a complete diagnosis is well worth the effort. It may be very helpful to cooperate with internists and neurologists to determine successful treatment plans for patients suffering from neuropathies. Clients need to be counseled early on that these conditions may not respond and may even continue to deteriorate, even if the correct causation is determined.

Medical therapy rationale, drug(s) of choice, and nutritional recommendations

Medical therapy depends upon the underlying cause. If properly diagnosed and treated, the hope is that the neuropathy will resolve. Immune-mediated neoplasia most often require ongoing immunosuppressing therapies such as corticosteroids and chemotherapeutics.

Anticipated prognosis

The prognosis depends upon determining the underlying cause. Generally, a response is seen 1 to 3 months after initiating the therapy. The prognosis is poor to guarded if there is no response to the initial medical therapy.

Integrated veterinary medicine

The underlying process is inflammation of the central nervous system. While the specific cause is not reported, inflammation and immune-mediated processes most often necessitate the selection of corticosteroids as the primary therapy. The integrative approach, therefore, is to use nutrients, nutraceuticals, medicinal herbs, and combination homeopathics that have anti-inflammatory properties and can help to balance the immune system and reduce an exaggerated response. Clinicians should use any appropriate therapy in these cases; integrative therapy using conventional medicine, nutrition, and biological agents may speed recovery and improve patient comfort.


General considerations / rationale

While medical therapy is focused locally upon inflammation, the nutritional approach adds glandular support for the organs of the immune system as well as nutrients to help improve brain and nerve function.

Note: Because granulamatous meningoencephalitis and its symptoms can range from local to systemic, it is recommended that blood be analyzed both medically and physiologically to determine concurrent disease. This helps clinicians to formulate therapeutic nutritional protocols that address the central nervous system as well as other organ systems (see site, Nutritional Blood Testing, for additional information).

Appropriate nutrients

Nutritional / gland therapy: Glandular brain, nerve, adrenal, and thymus supply the intrinsic nutrients that help to reduce cellular inflammation and improve nerve and immune function. This helps to spare the brain and nerve from ongoing immune attack and helps slow degeneration and loss of function (see Gland Therapy in site for a more detailed explanation).

Phospholipids found in glandular brain are a source of unsaturated omega-3 fatty acids, which are now thought to play a vital role in the development and maintenance of the central nervous system. High concentrations of phosphatidyl choline and serine are found in brain tissue. Horrocks (1986) reported on the potential clinical use of these nutrients in chronic neurological conditions.

Phosphatidyl serine: Phosphatidyl serine is a phospholipid that is essential for the integrity of cell membranes, particularly those of nerve and brain cells. It has been studied extensively in people with impaired mental functioning and degeneration with positive results.

Lecithin / phosphatidyl choline: Phosphatidyl choline is a phospholipid that is integral to cellular membranes, particularly those of nerve and brain cells. It helps to move fats into the cells and is involved in acetylcholine uptake, neurotransmission, and cellular integrity. As part of the cell membranes, lecithin is an essential nutrient required by all of the body’s cells for general health and wellness.

Magnesium: Physiologically, magnesium activates adenosine triphosphatase, which is required for the proper functioning of the nerve cell membranes and fuels the sodium potassium pump. Magnesium is associated with neuromuscular function and conditions such as muscle cramping, weakness, and neuromuscular dysfunction. Magnesium is recommended for therapy for epilepsy and weakening muscle function.

Sterols: Plant-derived sterols such as betasitosterol show anti-inflammatory properties that appear to be similar to corticosteroids. A cortisone-like effect without the associated immune suppressing effects is beneficial in any inflammatory process in the central nervous system. Bouic reports on the immune enhancing and balancing effect of plant sterols that are also beneficial to animals with immune-mediated diseases.

Essential fatty acids: Research also confirms the benefits of essential fatty acids’ calming effect on the central nervous system.

Chinese herbal medicine / acupuncture

General considerations / rationale

Granulamatous meningoencephalitis is a combination of External Wind, Heat, and Toxin invading the Ying and Blood, which affects Wei and Qi at the same time. This leads to Heart and Pericardium disturbances.

Peripheral neuropathy may be a result of trauma or it may be due to Cold and Wind invasion, leading to Qi and Blood stagnation in the Meridians.

In granulamatous meningoencephalitis, the Wind blows the pathogenic influence into the body. Heat and Toxins then invade the Ying and Blood layers of the body. The Heat refers to fever and inflammation. Toxins are the substances that cause the inflammation. Wei is the immune system, so there is a disruption of immunoregulation, which is in agreement with the Western understanding of an immune basis to this disease. Neurological signs appear when the Ying level is affected. At the Xue level, the Heart and Pericardium, which house and protect the mind, are disturbed. When this occurs, the patient does not react properly to the environment. This can explain the seizures with the attendant loss of consciousness.

Treatment is aimed at decreasing the inflammation, fever, and pain, and normalizing the neurological function.

In peripheral neuropathy the ancient Chinese physicians were well aware of the ability of trauma to damage nerves. When they could not point to trauma as a cause, they theorized that Wind blew Cold into the body. Cold was able to slow the transit of Blood and Qi in the Meridians. Without a normal flow of Blood and Qi, the limbs could not function properly. Treatment is aimed at normalizing limb function.

Appropriate Chinese herbs for granulamatous meningoencephalitis

Achyranthes (Niu xi): Has shown analgesic effects. In mice it was shown to decrease pain reactions to body torsion and hot plates. It also demonstrated anti-inflammatory effects.

Arctium Niu bang zi: Has anti-inflammatory and antipyretic effects.

Buffalo horn shaving (Niu jiao): A strong pain reliever that also decreases edema.

Coix (Yi yi ren): Can help control pain and inflammation. It helps prevent carrageenin-induced foot swelling and dimethylbenzene-induced ear swelling in mice. A study involving 26 women with severe dysmenorrhea found that coix significantly decreased pain by more than 90%.

Forsythia (Lian qiao): Has anti-inflammatory, analgesic, and anti-pyretic effects and can prevent edema.

Gastrodia (Tian ma): Can help decrease pain. It decreases the level of dopamine in the brain, and this may be responsible for the analgesic effect (Huang 1993). It was shown to decrease agar-induced swelling in mice and carrageenin- and 5-HT-induced swelling in the feet of rats. This anti-inflammatory action may be useful in treating granulamatous meningoencephalitis.

Grass-leaf sweet-flag root (Shi chang pu): Contains alpha-asarone, which demonstrated an efficacy of approximately 85% in treating seizures in a group of 90 people. It may help decrease seizures in patients with granulamatous meningoencephalitis.

Honeysuckle (Jin yin hua): An anti-inflammatory and antipyretic herb.

Isatis (Da qing ye): Has anti-inflammatory effects.

Licorice (Gan cao): Contains glycyrrhizin and glycyrrhetinic acid, which have anti-inflammatory effects. They have approximately 10% of the corticosteroid activity of cortisone. They decrease edema and decrease the formulation of granulomas.

Lophatherum (Dan zhu ye): An antipyretic herb.

Mint (Bo he): Decreases fever and inflammation.

Platycodon (Jie geng): Contains platycodin, which has antipyretic effects. It also has anti-inflammatory effects via its ability to increase corticosterone secretion.

Pueraria (Ge gen): Reduces fevers (Modern traditional Chinese medicine Pharmacology 1997).

Schizonepeta (Jing jie): Has analgesic properties.

Scutellaria (Huang qin): Contains baicalin and biacalein, which have been shown to suppress inflammation in mice. It also can lower fever.

Silkworm (Jiang can): Has been shown to be effective in stopping experimentally induced seizures in mice. In one trial, 77% of humans with epilepsy who were treated with Jiang responded well. This suggests that it may help reduce seizure activity in patients with granulamatous meningoencephalitis.

Uncaria (Gou teng): Has been proven to prevent seizures in animals.

Acupuncture for granulamatous meningoencephalitis

The World Health Organization recognizes the efficacy of acupuncture for the treatment of headache (World Health Organization 2006). In addition, acupuncture has been shown to be better than phenobarbital at stopping fever-induced seizures in children. This may have a dual effect of addressing both the seizure and fever aspects of granulamatous meningoencephalitis.

Appropriate Chinese herbs for forelimb neuropathies

Angelica root (Dang gui): Increases phagocytic activity of macrophages, which may help patients with infectious peripheral neuropathies. It also decreases inflammation, which may make it beneficial in inflammatory etiologies.

Astragalus (Huang qi): Can improve humoral and cellular immune functions, which may help in the case of bacterial or viral neuropathies.

Centipede (Wu gong): Has antibiotic properties. It inhibits cancer cells in vitro, which indicates that it may be useful for neuropathies secondary to these causes.

Cinnamon twig (Gui zhi): Inhibits some bacteria and viruses.

Earthworm (Di long): Has anti-neoplastic effects. The mechanism is not yet elucidated, but it may be due to enhanced immunity and scavenging of free radicals. This may help in some forms of neoplastic neuropathy.

Jujube fruit (Da zao): Can inhibit dimethylbenzene-induced ear swelling in mice, and egg white-induced toe swelling in rats. It may also ameliorate inflammatory neuritis.

Licorice (Gan cao): Inhibits bacteria and viruses. It may be efficacious in viral and bacteria-mediated neuropathies.

Milettia (Ji xue teng): Has antiviral effects. It has been shown to inhibit herpes virus I (simplex), a virus known to be neurotropic. In addition, it has demonstrated activity against cancers via increased NK activity in mice.

Rehmannia / cooked (Shu di huang): May help improve the conditions of nerves. One trial examined the results of an herbal supplement containing rehmannia with Rou cong rong, Lu han cao, Gu sui bu, Yin yang huo, Ji xue teng, and Lai fu zi in 1,100 patients with myelitis. 73% had significant improvement, and another 13% had moderate improvement in clinical signs.

Tumeric (Jiang huang): May decrease neuronal inflammation. It inhibits MIP-2 (macrophage inflammatory protein-2) production. This chemical has been implicated in traumatic brain injury, which strongly suggests applicability in patients with neuropathy.

White peony (Bai shao): Contains paeoniflorin, which is a strong anti-inflammatory. In addition, it seems to have a neurotropic effect. It contains gallotannin, which prevents neuron damage in mice with cobalt-induced seizures (Sunaga 2004). This may make it a powerful herb for decreasing neuronal inflammation.

Wild ginger (Xi xin): Inhibits carrageenin-induced foot swelling. It may prevent inflammation in the nervous system, thereby treating inflammatory neuropathies.

Appropriate Chinese herbs for hindlimb neuropathies

Achyranthes (Niu xi): Decreases egg-white-induced foot swelling in rats. It may help decrease inflammation in the nervous system.

Alpinia (Yi zhi ren): Has demonstrated some anti-neoplastic activity.

Antler powder (Lu jiao jiao): Enhances the phagocytic function of macrophages and can be used as an adjuvant in cancer treatment.

Astragalus (Huang qi): See forelimb paralysis, above.

Cornus (Shan zhu yu): Can inhibit carrageenin-induced toe swelling in rats and mice. This suggests that it may be useful in cases of inflammatory etiologies.

Dioscorea (Shan yao): Stimulates both the humoral and cellular immune system. It may help with infectious causes of neuropathy.

Eucommia (Du zhong): Contains chlorogenic acid, which has antibacterial effects. It stimulates cellular immunity, which may make it useful when the neuropathy is due to infectious etiologies.

Ophiopogon (Mai men dong): Effective against Staphylococcus albus, Bacillus subtilis, E. coli, and Salmonella typhi.

Papaya (Mu gua): Has inhibitory effects on tumors.

Poria (Fu ling): Has antibiotic effects. It also stimulates cellular immunity. Finally, it has demonstrated anti-neoplastic activity.

Rehmannia / cooked (Shu di huang): See forelimb paralysis, above.

White atractylodes (Bai zhu): Has demonstrated anti-neoplastic efficacy.

Appropriate Chinese herbs for facial neuropathies

Angelica root (Dang gui): See forelimb neuropathies, above.

Centipede (Wu gong): See forelimb neuropathies, above.

Cnidium (Chuang xiong): Increases the phagocytic function of macrophages. It may be helpful in infectious neuropathies.

Gastrodia (Tian ma): Decreases nerve pain from toxins and vascular causes.

Ginseng (Ren shen): Prevents the decrease in plasma T3 and T4 levels as laboratory animals age. It may be useful in hypothyroid-induced neuropathies.

Siler (Fang feng): Has antibiotic properties. It is also anti-neoplastic.

Silkworm (Jiang can): Can inhibit some bacteria.

White aconite (Bai fu zi): May help with facial nerve disorders. In one study, 90% of 418 people with facial numbness recovered completely when an herbal formula containing typhonium (Bai fu zi), angelica root (Dang gui), scorpion (Quan xie), sick silkworm (Jiang can), and centipede(Wu gong) was injected into acupoints.


General considerations / rationale

Granulamatous meningoencephalitis is an intracranial proliferative inflammatory process involving mesenchymal cells, which may present in a generalized inflammatory form or a mass form. The cause is unknown. Lymphocytes and macrophages are the primary inflammatory cells that are present (Bagley 2005).

There is no published material on this condition in any homotoxicology references, which makes the material that follows an academic discussion. Goldstein (2006) has successfully used the protocol below in combination with other integrative modalities discussed in this section.

Because connective tissue elements function in an abnormal and deleterious manner, this condition represents a disease to the right of the Biological Divide, most likely the Impregnation and Degeneration phases. There may be Dedifferentiation Phase factors involved. Examination of such cases for chemical or viral agents may prove interesting in researching the cause. Antihomotoxic agents discussed in the encephalitis / meningitis section are applicable. Phase remedies and deep detoxification with support of energy-producing enzyme systems represent a logical clinical approach to this condition. The expected prognosis is guarded. The use of drugs such as corticosteroids and immunosuppressants are warranted to preserve patient comfort and ability. As with all neurological problems, use of a qualified neurologist may be helpful in establishing the correct diagnosis and most current treatment options.

Selecting symptom remedies and detoxification protocols is extremely important in neurology cases. Many homeopathic and herbal agents have affinity for neural tissue in specific body regions (neck, face, lumbar spine, extremities), and the integrative clinician should always be sure to consider the anatomical region is designing proper treatment programs. In traumatic cases, the use of simple single antihomotoxic formulas such as Traumeel S may give immediate improvement. Most cases of peripheral neuropathies presented to veterinarians represent deeper homotoxicoses and require combinations of therapy and careful monitoring of progress. Always remember that the goal of therapy is regressive vicariation and that signs of inflammation and discharge may well represent the beginning of healing in a patient. Inherited conditions generally carry a guarded prognosis, but may improve or stabilize with biological therapies integrated with conventional medical handlings, and it is beneficial to have a basic understanding of these approaches when faced with a nonresponsive or difficult case.

The development of acutely painful conditions similar to shingles in humans may represent the movement of homotoxins from chronic Impregnation and Degeneration phases to the Inflammation Phase, and should be welcomed as a potentially good sign. Other neurological signs may occur during these regressive vicariations (i.e., altered awareness, personality changes, tics, and seizures) and may require experienced handling as the patient moves from right to left of the Six-Phase Table of Homotoxicology.

Appropriate homotoxicology formulas

Aesculus compositum: Useful in improving circulation following stroke or reduced cerebral circulation (Aesculus hippocastanum and Secale cornutum). Areteria suis supports the arteries. Solanum nigrum further supports cerebral function, particularly in cases with confusion, epileptic seizures, or disorientation. Several other agents support homotoxin removal and improve vessel stability.

Apis homaccord: Generally useful in edema, but also in cerebral sensitivity. May assist cardiac-induced cerebral weakness through Scilla, Apisinum, and Apis mellifica. The main symptoms of Apis may be summed up as follows for quick reference: sensitivity to touch and jarring; irritation of the meninges, especially from suppressed eruptions; diseases of the serosa, joints, and meninges; infiltration of the cellular tissues; and serous meningitis. Apis is also found in Aesculus compositum, Cerebrum compositum, Blacenta compositum, and Tonsilla compositum.

Arsuraneel: Used for patients not responding to initial therapy; this formula may move them into a recovery phase through stimulation of the general defenses. Useful in cases with seizures, anxiety, feeling worse at night, paresis, and muscular disability.

Belladonna homaccord: Belladonna, which has an affinity for the central nervous system, is useful in patients manifesting seizures and who scream out at night. Violent delirium is characteristic of Belladonna, above all in fever. Belladonna’s typical action on the eyes is also well-known, with cramps in the muscles of the eyes and eyelids, enlargement of the pupils and, in particular, an inflammatory or irritative condition of the conjunctiva with marked photophobia, lachrymation, and pain. Belladonna is indicated in incipient boils, tonsillitis, and surface inflammations such as erysipelas, conjunctivitis, scarlet fever, otitis, cholangitis, meningitis, and other inflammatory affections. A delirious state occurs with a violent rise in temperature with considerably raised sensitivity of all the senses and a disproportionate sensitivity to touch, noises, light, cold air — especially draughts and jarring — as can be the case in meningitis. Along with nasal catarrhs, there may be catarrhs of the larynx and trachea, with slight mucus, accompanied a typical cough, which is dry, rough, and barking, with hoarseness. In the digestive organs, Belladonna affects acute gastric catarrhs. Belladonna is also common to Traumeel, Spigelon, Viburcol, BHI-Inflammation, BHI-Neuralgia, and BHI-Recovery formulas.

BHI-Inflammation: Contains Rhus toxicodendron for cases of weakness and paresis. Cases may be aggravated after lying in wet grass. Patients that benefit may have pustular, pruritic skin conditions; joint pain; myelitis; vertigo / dizziness; intercostal pain; and other types of neuralgia. Commonly used in combination with other antihomotoxic agents.

Bryaconeel: Used for neuralgia, serous membrane inflammation such as meningitis (Bryonia cretica), acute feverish conditions, and influenza-like signs. Contains Phosphorus to support parenchymatous organs such as the lung and liver. Moderates severe or overaggressive vicariations. Used in meningitis in cases not responsive to primary therapy.

Cerebrum compositum: Supports cerebral tissue, stem cells, and vessels (Cerebrum suis, Placenta suis, Arnica montana). Treats memory loss and forgetfulness and improving memory (Selenium, Thuja occidentalis, Acidum phosphoricum, Manganum phospohoricum, Semecarpus anacardium, Ambra grisea, Conium maculatum, Medorrhinum-Nosode). Supports cerebral function and vascular structures (Kalium phophoricum). Treats vertigo, stupor, headache, and weakness (Gelsemium sempervirens, Kalium bichromicum, Ruta graveolens) anxiety (Aconitum napellus), and exhaustion (China, Amarita cocculus). Supports capillary and other circulation, as well as lymph (Aesculus hippocastanum) and enzyme systems and difficulty sleeping (Hyoscyamus niger).

Coenzytne compositum: Supports energy production through enzyme induction and repair, and is useful in repairing damage to enzyme systems of metabolism and following administration of drugs injurious to metabolism. Sulfhydral groups in Cysteinum assist in repairing therapeutic damage and in cases of forelimb weakness. Phase remedy in Degeneration and Dedifferentiation phases.

Cruroheel: Has strong connective tissue effects and is useful in difficult cases or those with strong vicariations.

Discus compositum: Clears the deep matrix and supports connective tissue repair, and treats irritation originating in the spinal column. Contain a number of useful remedies that particularly benefit musculoskeletal function, including Funiculus umbicalis suis (also contained in Cutis compositum, Blacenta compositum, Tbyroidea compositum, Tonsilla compositum, and Zeel) for debility. Treats arteriosclerosis, cervical spondylosis, collagen diseases, scleroderma, fibromas, vascular pathology, geriatric indications of all kinds, dystonia of the autonomic nervous system, autoimmune diseases, damage from antibiotics and other drugs, general iatrogenic damage, multiple sclerosis, and muscular atrophy. Also contains Niconitamidum, which is used to activate the energy metabolism in insufficiencies of the respiratory chain. The substance, which occurs naturally in the body, is an important component of NAD and NADP. Treats deficiencies of Nicotinamidum that lead to mental and neurological disturbances. It is common to the remedies Coenzytne compositum, Discus compositum, Ginseng compositum, Ubichinon compositum, Zeel, and BHI-Enzyme.

Echinacea compositum: Contains Aconitum, which is indicated for catarrhs, neuralgic symptoms with paresthesia, hyperthermia, and encephalitis with very high temperatures (e.g. post-vaccinial encephalitis or meningo-encephalitis, which may be activated by the implantation of living cells). Low potencies are normally given in pyrexia and organic complaints. The component Aconitum is common to several useful remedies, including Barijodeel, Bryanconeel, Cerebrum compositum, Gripp-Heel, and Traumeel. Baptisia is included for meningitis and encephalitis, serious feverish infections, general blood poisoning, and states of confusion. Aesculus compositum, Arnica-Heel, and other complexes are also included.

Engystol N: Has antiviral effects through immunostimulation.

Galium-Heel: Phase remedy in the matrix and cellular phases. Provides powerful support of the immune system (Echinacea augustifolia). Assists in drainage of cell and matrix, supports renal tubular function, and decreases swelling and edema (Apis mellifica, Galium aparine, and Galium mollugo). It is a critical component in the deep detoxification formula. Doses should be administered with regard to clinical condition and response, with the dose reduced if strong reactions are noted.

Gelsemium homaccord: Treats neuralgia and nerve pain, headache, and posterior weakness. Commonly required in aging large-breed dogs. This is a major antihomotoxic agent used in many neuropathy cases. Think of this agent in trembling pets because Gelsemium is known as the “trembling” remedy.

Ginseng compositum: Treats eyelid weakness and exhaustion.

Glyoxal compositum: Provides mitochondrial repair of damaged enzyme systems in Degeneration and Dedifferentiation phase disorders.

Listeriosis nosode: This remedy is not available in any of the homotoxicology combinations, but could be useful as a single remedy. The zoonotic organism Listeria monocytogenes causes a disease characterized by granulomatous meningoencephalitis in small animals.

Lymphomyosot: Used after cortisone therapy and for mesenchymal purging in chronic disease states.

Neuralgo-Rheum-Injeel: The components Causticum Hahnemanni and Rhus toxicodenron are powerful neurological remedies that cover a wide variety of chronic rheumatic-arthritic complaints, skin conditions, and intercostalsciatic neuralgias.

Placenta compositum: Supports hypophysis after cortisone therapy. Contains sulfur to support enzyme and metabolic repair. Regenerative of hypophyseal-adrenal axis, and repairs vascular structures. Used intermittently in endocrine disorders.

Psorinonheel: Useful in deep, constitutional / genetic homotoxicoses. Consider in experimental application in inherited conditions. This remedy contains Cicuta, which is indicated for meningitis with hypersensitivity. It is a complementary remedy in tuberculous meningitis.

Solidago compositum: Deposition Phase remedy needed to remove debris from the matrix after regressive vicariation begins. In Traditional Chinese Medicine, the Kidney Chi governs the Brain, and as such, neurological issues may benefit from support of the Kidney and related tissues. Part of the deep detoxification formula. An interesting indication in this remedy is for Coxsackie virus nosode, which is used for abacterial meningitis and encephalitis.

Spigelon: Helpful for symptoms of headache, cerebral conditions with inflammation, and weakness of connective tissues.

Thyroidea compositum: Used for matrix drainage and autoregulation repair. Contains low levels of thyroid, pineal, spleen, bone marrow, umbilical cord, and liver to support glandular function and repair. Galium aparine drains the matrix and cellular components. Cortisonum aceticum in low potency assists in repairing damage from excess levels of cortisone. Precursors and Krebs cycle constituents promote energy metabolism through the Michae-lis-Menten law of enzyme activity. Pulsatilla and Sulfur assist in regulation rigidity-type situations. Part of the deep detoxification formula.

Tonsilla compositum: Main antihomotoxic drug for chronic diseases involving endocrine disorders. Supports a wide number of tissues including tonsil, lymph node, bone marrow, umbilical cord (stem cell precursors), spleen, hypothalamus, liver, embryo, and adrenal cortex. Contains Cortisonum aceticum and thyroid hormone in nanodilutions. Also contains Psorinum for deep constitutional, lack of reaction cases. Degeneration Phase agent.

Ubichinon compositum: Provides mitochondrial repair of energy production mechanisms. Used in chronic diseases and iatrogenic injury to mitochondria from antibiotic therapy, and is part of the deep detoxification formula. Parabenzochinon, a critical component in this regard, is indicated for autoimmune issues, and has been recommended for a state of paresis occurring after poliomyelitis, encephalitis or vaccinations, disturbance in neuromuscular coordination, conditions such as multiple sclerosis and tumors in the spinal area with pains and paresis, and brain tumors. In many cases of meningeal irritation, parabenzoquinone deals with the terrible pains better than an opiate.

Authors’ suggested protocols


Brain / nerve and immune support formulas: 1 tablet for each 25 pounds of body weight BID.

Phosphatidyl serine: 25 mgs for each 25 pounds of body weight BID.

Lecithin / phosphatidyl choline: One-fourth teaspoon for each 25 pounds of body weight BID.

Betathyme: 1 capsule for each 35 pounds of body weight BID (maximum, 2 capsules BID).

Essential fats: One-half teaspoon for every 35 pounds of body weight with food.

Magnesium: 10 mgs for every 10 pounds of body weight SID.

Chinese herbal medicine / acupuncture

For granulamatous meningoencephalitis, the patent formula is Yin Qiao San. It contains arctium (Niu bang zi), forsythia (Lian qiao), honeysuckle (Jin yin hua), licorice (Can cao), lophatherum (Dan zhu ye), mint (Bo he), phragmites root (Lu gen), platycodon (Jie geng), schizonepeta (Jing jie), and soybean (Dan dou chi). It is dosed according to the manufacturer’s recommendation. Yin Qiao San has been shown experimentally to decrease inflammation. It inhibited dimethlybenzine-induced increase in skin capillary permeability. It also has antipyretic effects similar to aspirin. In addition it has been shown to have antibacterial and antiviral efficacy (Shanghai Health and Epidemic Prevention Station 1960). Finally, it has analgesic properties as demonstrated using hot plate and acetic torsion experiments in mice. It was used to treat encephalitis B in 37 people with good response. In another study on people with encephalitis (nonspecified origin), 74 of 81 people recovered completely, 2 did not respond completely and 5 people died.

An alternative herbal supplement is H25 granulamatous meningoencephalitis Disorder at a dose of 1 capsule per 10 to 20 pounds twice daily. In addition to the herbs in Yin Qiao San, H25 granulamatous meningoencephalitis also contains achyranthes (Niu xi), buffalo horn shavings (Niu jiao), chrysanthemum (ju hua), coix (Yi yi ren), gastrodia (Tian ma), grass-leaf sweet-flag root (Shi chang pu), hoelen spirit (Fu shen), isatis leaf (Da qing ye), isatis root (Ban Ian gen), papaya (Mu gua), phellodendron (Huang bai), pueraria (Ge gen), scutellaria (Huang qin), silkworm (Jiang can), and uncaria (Gou teng).

These formulas can be combined with conventional drugs, but often are only needed for a short period of time.

The author uses the following acupuncture points for granulamatous meningoencephalitis: ST36, GV14, CV17 and GB20.

For forelimb neuropathies, the authors recommend H41 Forelimb Paralysis at a dose of 1 capsule per 10 to 20 pounds twice daily. In addition to the herbs discussed above, H41 Forelimb Paralysis contains codonopsis (Dang shen) and scorpion (Quan xie), which increase the efficacy of the formula.

The author recommends the following acupuncture points: LIU, SI9, TH6, LI10, ST36, and Bai Hui.

For hindlimb neuropathies the authors recommend H 72 Hindlimb Paralysis / Incontinence at a dose of 1 capsule per 10 to 20 pounds twice daily. In addition to the herbs mentioned above, H72 Hindlimb Paralysis / Incontinence contains American ginseng (Xi yang shen), ciborium (Gou ji), cynomorium (Suo yang), fossil bones / raw (Long gu), lindera (Wu yao), mantis egg case (Sang piao xiao), polygonatum (Yu zhu), and tortoise plastron (Gui ban). These herbs enhance the function of the herbal supplement.

The author uses the following acupuncture points: ST36, UB60, BL30, and Bai Hui.

For facial neuropathies the authors use H 73 Facial Nerve Paralysis at a dose of 1 capsule per 10 to 20 pounds twice daily. In addition to the herbs listed above, H 73 Facial Nerve Paralysis contains scorpion (Quan xie) to improve the efficacy of the formula.

The author recommends the following acupuncture points: ST4, ST6,ST7, and SI9.


Deep detoxification may assist noninherited conditions, and support of energy metabolism through the use of catalysts should be considered. Use of antihomotoxic agents that match the patient’s symptoms may be helpful. Treatment must be individualized to the specific patient’s needs. Any clinician successfully treating either inherited or acquired polyneuropathies should report their findings for publication.

GME (granulamatous meningoencephalitis)

Symptom formula: Two protocols exist.

1. Administer Echinacea compositum IV and Solidago compositum and Galium-Heel as an autosanguis, and dispense anoral cocktail consisting of Traumeel, Psorinoheel, and Aesculus compositum BID to TID. Use Ubichinon compositum orally BID. Administer Spigelon for pain and inflammation associated with the illness, and consider Listeria nosode, obtained from a single remedy company, or Heel-Germany.

2. Administer Gelsemium homaccord, BHI-Inflammation, Spigelon, and Traumeel S mixed together and given PO BID for 3 weeks, then alternate with Pulsatilla compositum in an attempt to shift regulation rigidity. Give Cerebrum compositum 1 to 3 times weekly. Consider autosanguis therapy.

Deep detoxification formula: Galium-Heel, Lymphomyosot, Hepar compositum, Solidago compositum, Thyroidea compositum (alternated with Tonsilla compositum in inflammatory conditions), Coenzyme compositum, and Ubichinon compositum combined and given orally twice weekly. Consider giving these and the above symptom formula agents as autosanguis therapy.

Acquired peripheral neuropathies

In nearly all cases it would be appropriate to administer Neuralgo-Rheum and Discus compositum 2 to 3 times weekly by injection.

Deep detoxification formula: Galium-Heel, Lymphomyosot, Hepar compositum, Solidago compositum, Thyroidea compositum (alternated with Tonsilla compositum in inflammatory conditions), Coenzyme compositum, and Ubichinon compositum combined and given orally twice weekly. Consider giving these agents as autosanguis therapy.

Diabetic polyneuropathy

Lymphomyosot, Syzygium compositum, and Mucosa compositum given orally in conjunction with alpha-lipoic acid. (See also Diabetes mellitus protocol).

Hypothyroid polyneuropathy

Administer in addition to proper thyroid hormone replacement therapy. Thyroidea compositum given twice weekly alone or as part of the deep detoxification formula if the condition is stable.

Iatrogenic pharmaceutical injury (vincristine, vinblastine, and colchicines)

Deep detoxification formula, IV fluid support, and avoidance of the offending drug until it can be cleared.


Deep detoxification formula, and also consider BHI-Body Pure for 1 to 3 months.

Immune-mediated (autoimmune such as systemic lupis erythmatosis)

See autoimmune protocols.

Infectious (Neospora caninum and FeLV)

Use clindimycin for Neospora. See the FeLV protocol section. Tonsilla compositum given twice weekly and Echinacea compositum daily by injection during acute involvement. Engystol may improve immune function given daily. Traumeel S if acute inflammation or swelling is involved.

Toxic injury (metals, solvents such ascarbon tetracycline, organophosphate, insecticides)

Deep detoxification formula in conjunction with appropriate antidote, plus supportive and chelation therapy.

Product sources


Brain / nerve and immune support formulas: Animal Nutrition Technologies. Alternatives: Immune System Support — Standard Process Veterinary Formulas; Immuno Support — Rx Vitamins for Pets; Immugen — Thorne Veterinary Products.

Phosphatidyl serine: Integrative Therapuetics.

Lecithin / phosphatidyl choline: Designs for Health.

Betathyme: Best for Your Pet. Alternative: Moducare Thorne Veterinary Products.

Beyond essential fats: Natura Health Products. Alternatives: Flax oil — Barlean’s Organic Oils; Hemp oil — Nature’s Perfect Oil; Ultra EFA — Rx Vitamins; Omega- 3,6,9 — Vetri Science.

Magnesium: Over the counter.

Chinese herbal medicine

Yin Qiao San: Mayway Corp.

Formulas H25 granulamatous meningoencephalitis, H41 Forelimb Paralysis, H72 Hindlimb Paralysis / Incontinence, and H73 Facial Nerve

Paralysis: Natural Solutions, Inc.


BHI / Heel Corporation