Tag Archives: Allopurinol

Allopurinol (Zyloprim)

Xanthine Oxidase Inhibitor; Purine Analog Highlights Of Prescribing Information • Used as a uric acid reducer in dogs, cats, reptiles & birds & as an alternative treatment Leishmaniasis &Trypanosomiasis in dogs • Use with caution (dosage adjustment may be required) in patients with renal or hepatic dysfunction • Contraindicated in red-tailed hawks & should be… Read More »

Musculoskeletal Disorders

Lameness, the primary clinical sign seen with musculoskeletal disease, can be caused by a wide variety of illnesses and syndromes. Certainly one prevalent cause of lameness is sore feet due to poor perches. Perches that are too large or are covered with ridges or sandpaper are the major culprits. Nutritional deficiencies, such as vitamin A… Read More »

Antiprotozoal drugs

Protozoal infections affect many species; causative protozoa and effective drug treatments are listed in Table Drugs effective against protozoal infections. Medicated feedingstuffs, that were previously authorised as pml in the UK, are now zootechnical feed additives authorised under and used in accordance with the relevant Annex entry of Directive 70/524/EEC (The Feedingstuffs (Zootechnical Products) Regulations… Read More »

Drugs for leishmaniosis

Leishmania spp. are vector-borne protozoan parasites primarily affecting dogs. The protozoa are transmitted by various species of sandflies belonging to the genus Phlebotomus. In Mediterranean Europe, canine visceral leishmaniosis is caused by L. infantum. The disease is zoonotic with dogs acting as a reservoir host. Infection in dogs causes a chronic insidious systemic disease characterised… Read More »

Dactinomycin

Chemistry An antibiotic antineoplastic agent, dactinomycin (also known as actinomycin D) occurs as a bright red, crystalline powder. It is somewhat hygroscopic and soluble in water at 10°C and slightly soluble at 37°C. The commercially available preparation is a yellow lyophilized mixture of dactinomycin and mannitol. Storage – Stability – Compatibility The commercially available powder… Read More »

Cyclophosphamide

Chemistry A nitrogen-mustard derivative, cyclophosphamide occurs as a white, crystalline powder that is soluble in water and alcohol. The commercially available injection has pH of 3 to 7.5. Cyclophosphamide may also be known as CPM, CTX or CYT. Storage – Stability – Compatibility Cyclophosphamide tablets and powder for injection should be stored at temperatures less… Read More »

AZATHIOPRINE

AZATHIOPRINE SODIUM Chemistry Related structurally to adenine, guanine and hypoxanthine, azathioprine is a purine antagonist antimetabolite that is used primarily for its immunosuppressive properties. Azathioprine occurs as an odorless, pale yellow powder that is insoluble in water and slightly soluble in alcohol. Azathioprine sodium powder for injection occurs as a bright yellow, amorphous mass. After… Read More »

ALLOPURINOL

Chemistry A xanthine oxidase inhibitor, allopurinol occurs as a tasteless, fluffy white to off-white powder with a slight odor. It melts above 300° with decomposition and has an apparent pKa of 9.4. Oxypurinol (aka oxipurinol, alloxanthine), its active metabolite, has a pKa of 7.7. Allopurinol is only very slightly soluble in both water or alcohol.… Read More »