Tag Archives: Aminocaproic acid

Aminocaproic Acid (Amicar)

Fibrinolysis Inhibitor/Antiprotease Highlights Of Prescribing Information • May be useful for treating degenerative myelopathies in dogs; efficacy not well documented • Treatment may be very expensive, especially with large dogs • Contraindicated in DIC • Infrequently causes GI distress What Is Aminocaproic Acid Used For? Aminocaproic acid has been used as a treatment to degenerative… Read More »

Acetylcysteine (N-acetylcysteine, Mucomyst, NAC)

Antidote; Mucolytic Highlights Of Prescribing Information • Used primarily as a treatment for acetaminophen or phenol toxicity & for its mucolytic effect; used anecdotally for treating degenerative myelopathy • Also used as a topical ophthalmic () • Has caused hypersensitivity & bronchospasm when used in pulmonary tree • Administer via gastric- or duodenal tube for… Read More »

Hemostatic Disorders

Coagulation and the formation of platelet-mediated hemostasis are important defense mechanisms against hemorrhage. Disruption between the balance of fibrinolysis and coagulation results in hemorrhagic and/or thrombotic disease. Hemostatic disorders can be inherited or acquired in origin. Inherited coagulation disorders are rare and primarily affect the intrinsic coagulation pathway. Acquired hemostatic disorders involve blood vessels, platelets,… Read More »

Acute Blood Loss

The pathophysiologic effects of acute blood loss result from decreased circulating blood volume and associated hypovolemic shock. Hemorrhage becomes clinically significant when over 30% of the body’s blood is lost rapidly. Because blood volume represents approximately 8% of body weight, this loss constitutes 10.8 liters in a 450-kg horse. Unfortunately, accurate quantification of blood loss… Read More »

Algorithm For Emergency Treatment Of Hemorrhage In The Broodmare

A simplified, step-by-step, sample flow chart for hemorrhage treatment is outlined below. The clinician should keep in mind that this outline describes an attempt to treat what should be a surgical problem, medically. One can only surmise at the nature of the internal insult. Periodic evaluation of the mare without quantification of the severity of… Read More »

Degenerative myelopathy

Definition and cause Degenerative myelopathy is a slow, progressive degeneration of the spinal cord, which often leads to loss of motor control of the hind legs. While no proven cause is known, it is believed that an autoaggressive process may be involved with the observed degeneration of the spinal cord. Although it is most commonly… Read More »

AMINOCAPROIC ACID

Chemistry An inhibitor of fibrinolysis, aminocaproic acid is a synthetic monamino carboxylic acid occurring as a fine, white crystalline powder. It is slightly soluble in alcohol and freely soluble in water and has pKa’s of 4.43 and 10.75. The injectable product has its pH adjusted to approximately 6.8. Aminocaproic acid may also be known by… Read More »