Tag Archives: Amphotericin B

Diseases of the Ear: General Principles Of Management

The therapeutic plan for otitis externa requires identification of the primary disease process and perpetuating factors. Ideally management is aimed at thoroughly cleaning and drying the ear canal, removing or managing the primary factors, controlling perpetuating factors, administering appropriate topical or systemic therapy (or both), and evaluating response to therapy. Ear Cleaning Ear cleaning serves… Read More »

Therapy For Specific Diseases Of The External Ear Canal

Ectoparasites Thorough cleaning of the external ear canal, treatment of all household pets, and whole-body therapy should be considered in the treatment regimen for ear mites. Pets with no clinical signs may be asymptomatic carriers and a reservoir for reinfestation. Otic parasiticides such as pyrethrins, rotenone, amitraz, and carbaryl must be administered every 24 hours… Read More »

Amphotericin B Desoxycholate, Amphotericin B Lipid-Based (Abelcet, Fungizone)

Antifungal Highlights Of Prescribing Information • Systemic antifungal used for serious mycotic infections • Must be administered IV • Nephrotoxicity is biggest concern, particularly with the deoxycholate form; newer lipid based products are less nephrotoxic & penetrate into tissues better, but are more expensive • Renal function monitoring essential • Amphotericin B Desoxycholate, Amphotericin B… Read More »

Acquired Pericardial Effusions: Specific Causes, Epidemiology, Treatment, and Prognosis

Idiopathic Pericardial Effusion Idiopathic pericardial effusion is a diagnosis of exclusion. It is made in cases with pericardial effusion where no intrapericardial masses are identified after thorough echocardiographic evaluation and the results of ancillary tests, such as pericardial fluid analysis, fail to disclose a cause. Pericardial histopathology and immunohistochemistry from dogs with idiopathic pericardial effusion… Read More »

Amikacin Sulfate (Amikin, Amiglyde-V)

Aminoglycoside Antibiotic Highlights Of Prescribing Information • Parenteral aminoglycoside antibiotic that has good activity against a variety of bacteria, predominantly gram-negative aerobic bacilli • Adverse Effects: Nephrotoxicity, ototoxicity, neuromuscu-lar blockade • Cats may be more sensitive to toxic effects • Risk factors for toxicity: Preexisting renal disease, age (both neonatal & geriatric), fever, sepsis &… Read More »

Acetylcysteine (N-acetylcysteine, Mucomyst, NAC)

Antidote; Mucolytic Highlights Of Prescribing Information • Used primarily as a treatment for acetaminophen or phenol toxicity & for its mucolytic effect; used anecdotally for treating degenerative myelopathy • Also used as a topical ophthalmic () • Has caused hypersensitivity & bronchospasm when used in pulmonary tree • Administer via gastric- or duodenal tube for… Read More »

Fungi

Histoplasma capsulatum Cause of Fungi Histoplasmosis is a systemic fungal disease of dogs and cats caused by Histoplasma capsulatum. In the environment, H. histoplasma organisms are mycelial, saprophytic soil fungi. In infected tissue or when cultured at 30 to 37° C, the organism is a yeast. The fungus is endemic throughout most of the temperate… Read More »

Oomycetes

Pythium insidiosum Oomycetes: Cause Pythium insidiosum is an aquatic oomycete that causes severe gastrointestinal pathology in a range of hosts in the tropic and subtropic climates. Based on ribosomal RNA gene sequence data, members of the Class Oomycetes are phylogenetically distinct from the Kingdom Fungi and are more closely related to algae than to fungi.… Read More »

Algae

Prototheca zopfii and Prototheca wickerhatnii Algae: Cause Three species have been recognized within the genus Prototheca: P. stagnosa, P. wickerhatnii, and P. zopfii; a fourth species, P. salmonis, has been proposed. Of these three species, P. wickerhatnii and P. zopfii have demonstrated pathogenicity. Prototheca spp. are ubiquitous in nature and are found in sewage systems,… Read More »

Anti-infective eye preparations

Care should be taken to distinguish superficial ocular disease caused by infections from other conditions that may result in a red or inflamed eye. Where possible the causative organism should be identified and any initial choice of a broad-spectrum antibacterial, or combination of antibacterials, modified according to bacterial sensitivity data. The severity of an infection… Read More »