Tag Archives: Dobutamine

Dilated cardiomyopathy in the cat

The aetiology of primary dilated cardiomyopathy in the cat is unknown. Recent work has indicated a close association between dietary taurine deficiency and dilated cardiomyopathy. In the cat, taurine is an essential amino acid which is required for the conjugation of bile acids. The premise that taurine deficiency is one of the causative factors in… Read More »

Balanced vasodilators

Sodium nitroprusside Sodium nitroprusside is a potent arteriolar and venodilator drug with a similar mechanism of action to the organic nitrates, h has a very short duration of action and is administered by continuous intravenous infusion starting at an initial infusion rate of 1-5 μg kg-1 min-1. It reduces pulmonary and systemic vascular resistance decreasing… Read More »

Positive inotropic agents

An ideal positive inotropic agent should increase the force of contraction of cardiac muscle at a given degree of end-diastolic stretch without reducing efficiency of energy use, increasing the heart rate or predisposing to cardiac arrhythmias. The drug should also lack vasoconstrictor action on peripheral blood vessels. Drugs which enhance myocardial intracellular cyclic AMP concentration… Read More »

Supraventricutar tachydysrhythmias

Sinus tachycardia (heart rates greater than 160-180 bpm in the dog and 240 bpm in the cat respectively) can occur in response to pain> fright, fever, anaemia, circulatory shock and hyperthyroidism, all states where sympathetic tone to the heart increases and as a result, the rate of impulse generation and conduction is enhanced. Drugs such… Read More »

Amiodarone HCL (Cordarone, Pacerone)

Class III Antiarrhythmic Highlights Of Prescribing Information • Antidysrhythmic agent that can be used in dogs for arrhythmias associated with left ventricular dysfunction or to convert atrial fib into sinus rhythm; very limited experience warrants cautious use • May be useful in horses to convert atrial fib or V tach into sinus rhythm • Contraindicated… Read More »

Aminophylline Theophylline

Phosphodiesterase Inhibitor Bronchodilator Highlights Of Prescribing Information • Bronchodilator drug with diuretic activity; used for bronchospasm & cardiogenic pulmonary edema • Narrow therapeutic index in humans, but dogs appear to be less susceptible to toxic effects at higher plasma levels • Therapeutic drug monitoring recommended • Many drug interactions What Is Aminophylline Theophylline Used For?… Read More »

Dilated Cardiomyopathy: Acute Therapy

Treatment Goals The treatment goals depend on the type and severity of the clinical signs. If severely dyspneic the initial goal is to make it easier for the cat to breathe by removing pleural effusion, by reducing pulmonary edema pharmacologically, or by administering oxygen. If the primary problem is a marked reduction in perfusion leading… Read More »

Management of Chronic Mitral Valve Insufficiency

Ideally, therapy of chronic mitral valve insufficiency would halt the progression of the valvular degeneration. Improvement of valvular function by surgical repair or valve replacement would likewise stop further deterioration. However, no therapy is currently known to inhibit or prevent the valvular degeneration, and surgery is usually not technically, economically, or ethically possible in canine… Read More »

Acyclovir (Zovirax)

Antiviral (Herpes) Highlights Of Prescribing Information • Used primarily in birds for Pacheco’s disease; may be useful in cats for Herpes infection • If given rapidly IV, may be nephrotoxic • Oral use may cause GI distress • Reduce dosage with renal insufficiency • May be fetotoxic at high dosages What Is Acyclovir Used For?… Read More »

Patent Ductus Arteriosus

The circulation in the fetus differs from that in the adult. In fetal animals the ductus arteriosus develops from the left sixth embryonic arch and extends from the pulmonary artery to the descending aorta, where it diverts blood from the nonfunctional fetal lungs back into the systemic circulation. Prior to birth, the ductus diverts approximately… Read More »