Tag Archives: Heparin sodium

Amphotericin B Desoxycholate, Amphotericin B Lipid-Based (Abelcet, Fungizone)

Antifungal Highlights Of Prescribing Information • Systemic antifungal used for serious mycotic infections • Must be administered IV • Nephrotoxicity is biggest concern, particularly with the deoxycholate form; newer lipid based products are less nephrotoxic & penetrate into tissues better, but are more expensive • Renal function monitoring essential • Amphotericin B Desoxycholate, Amphotericin B… Read More »

Aminophylline Theophylline

Phosphodiesterase Inhibitor Bronchodilator Highlights Of Prescribing Information • Bronchodilator drug with diuretic activity; used for bronchospasm & cardiogenic pulmonary edema • Narrow therapeutic index in humans, but dogs appear to be less susceptible to toxic effects at higher plasma levels • Therapeutic drug monitoring recommended • Many drug interactions What Is Aminophylline Theophylline Used For?… Read More »

Amikacin Sulfate (Amikin, Amiglyde-V)

Aminoglycoside Antibiotic Highlights Of Prescribing Information • Parenteral aminoglycoside antibiotic that has good activity against a variety of bacteria, predominantly gram-negative aerobic bacilli • Adverse Effects: Nephrotoxicity, ototoxicity, neuromuscu-lar blockade • Cats may be more sensitive to toxic effects • Risk factors for toxicity: Preexisting renal disease, age (both neonatal & geriatric), fever, sepsis &… Read More »

Postpartum Hemorrhage

Postpartum hemorrhage in the broodmare is not an uncommon problem. Most mares that bleed do so within 12 hours after foaling; however, it is important to remember that a mare may develop a hemorrhage at any time during gestation or even days after parturition. Mares that have suffered a rupture of a major blood vessel… Read More »

Dimenhydrinate

Chemistry An ethanolamine derivative antihistamine, dimenhydrinate contains approximately 54% diphenhydramine and 46% 8-chlorotheophylline. It occurs as an odorless, bitter and numbing-tasting, white crystalline powder with a melting range of 102°-107°C. Dimenhydrinate is slightly soluble in water and is freely soluble in propylene glycol or alcohol. The pH of the commercially available injection ranges from 6.4… Read More »

Cyclophosphamide

Chemistry A nitrogen-mustard derivative, cyclophosphamide occurs as a white, crystalline powder that is soluble in water and alcohol. The commercially available injection has pH of 3 to 7.5. Cyclophosphamide may also be known as CPM, CTX or CYT. Storage – Stability – Compatibility Cyclophosphamide tablets and powder for injection should be stored at temperatures less… Read More »

Codeine Phosphate

Chemistry A phenanthrene-derivative opiate agonist, codeine is available as the base and three separate salts. Codeine base is slightly soluble in water and freely soluble in alcohol. Codeine phosphate occurs as fine, white, needle-like crystals or white, crystalline powder. It is freely soluble in water. Codeine sulfate’s appearance is similar to codeine phosphate, but it… Read More »

Cisplatin

Chemistry An inorganic platinum-containing antineoplastic, cisplatin occurs as white powder. One mg is soluble in 1 ml of water or normal saline. The drug is available commercially as powder for injection and as a solution for injection. The powder for injection occurs as a white, lyophilized powder that also contains mannitol, sodium chloride and HCl… Read More »

BLEOMYCIN SULFATE

Chemistry An antibiotic antineoplastic agent, bleomycin sulfate is obtained from Streptomyces verticullis. It occurs as a cream colored, amorphous powder that is very soluble in water and sparingly soluble in alcohol. After reconstitution, the pH of the solution ranges from 4.5-6. Bleomycin is assayed microbiologically. One unit of bleomycin is equivalent to one mg of… Read More »

BETAMETHASONE

BETAMETHASONE DIPROPIONATE BETAMETHASONE SODIUM PHOSPHATE Note: For more information refer to the post: Glucocorticoids, General information Chemistry A synthetic glucocorticoid, betamethasone is available as the base and as the dipropionate, acetate and sodium phosphate salts. The base is used for oral dosage forms. The sodium phosphate and acetate salts are used in injectable preparations. The… Read More »