Tag Archives: Phenytoin

Amikacin Sulfate (Amikin, Amiglyde-V)

Aminoglycoside Antibiotic Highlights Of Prescribing Information • Parenteral aminoglycoside antibiotic that has good activity against a variety of bacteria, predominantly gram-negative aerobic bacilli • Adverse Effects: Nephrotoxicity, ototoxicity, neuromuscu-lar blockade • Cats may be more sensitive to toxic effects • Risk factors for toxicity: Preexisting renal disease, age (both neonatal & geriatric), fever, sepsis &… Read More »

Positive Inotropes

Agents capable of increasing cardiac contractility can improve a patient’s strength and exercise capacity, thereby potentially enhancing the pet’s quality of life. Ideally, these compounds would concurrently promote mortality benefits by improving cardiac efficiency and limiting the activation of endogenous compensatory mechanisms (with their detrimental long-term consequences). Unfortunately, to date most of the potent agents… Read More »

Dimenhydrinate

Chemistry An ethanolamine derivative antihistamine, dimenhydrinate contains approximately 54% diphenhydramine and 46% 8-chlorotheophylline. It occurs as an odorless, bitter and numbing-tasting, white crystalline powder with a melting range of 102°-107°C. Dimenhydrinate is slightly soluble in water and is freely soluble in propylene glycol or alcohol. The pH of the commercially available injection ranges from 6.4… Read More »

Dihydrotachysterol

Chemistry A vitamin D analog, dihydrotachysterol (DHT) occurs as odorless, colorless or white crystals, or crystalline white powder. It is practically insoluble in water, sparingly soluble in vegetable oils, and soluble in alcohol. Dihydrotachysterol may also be known as dihydrotachysterol, dichysterol, or dihydrotachysterol- Storage – Stability – Compatibility All dihydrotachysterol products should be stored at… Read More »

Seizures

1. What is a seizure? A seizure is a paroxysmal, transitory disturbance of brain function that has sudden onset, ceases spontaneously, and is likely to recur. Although most veterinarians call the resulting effects (e.g., jerky movements, staring) a “seizure,” the seizure is the neuronal event itself. The observable manifestation is called “seizure activity.” 2. Why… Read More »

Herbs For Neurological Disorders

Traditional herbalists employ nervine herbs to treat disorders of the nervous system, including cognitive dysfunction, degenerative myelopathy, epilepsy, and paresis/ paralysis (IV disc disease). Any plant that affects the nervous system is called a nervine. Perhaps one of the most useful classes of traditional nervines are the nerve tonics. These include the adaptogens (for example,… Read More »

Diazoxide, Oral

Chemistry Related structurally to the thiazide diuretics, diazoxide occurs as an odorless, white to creamy-white, crystalline powder with a melting point of about 330°. It is practically insoluble to sparingly soluble in water and slightly soluble in alcohol. Storage – Stability – Compatibility Diazoxide capsules and oral suspensions should be stored at 2-30°C and protected… Read More »

Codeine Phosphate

Chemistry A phenanthrene-derivative opiate agonist, codeine is available as the base and three separate salts. Codeine base is slightly soluble in water and freely soluble in alcohol. Codeine phosphate occurs as fine, white, needle-like crystals or white, crystalline powder. It is freely soluble in water. Codeine sulfate’s appearance is similar to codeine phosphate, but it… Read More »

Clorazepate Dipotassium

Chemistry A benzodiazepine anxiolytic, sedative-hypnotic and anticonvulsant, clorazepate dipotassium occurs as a light yellow, fine powder that is very soluble in water and slightly soluble in alcohol. Storage – Stability – Compatibility Capsules and tablets should be stored in tight, light resistant containers at room temperature. Clorazepate dipotassium is unstable in the presence of water.… Read More »

Clonazepam

Chemistry A benzodiazepine anticonvulsant, clonazepam occurs as an off-white to light yellow, crystalline powder having a faint odor. It is insoluble in water and slightly soluble in alcohol. Storage – Stability – Compatibility Tablets should be stored in air-tight, light resistant containers at room temperature. After manufacture, a 5 year expiration date is assigned. Pharmacology… Read More »