Tag Archives: Sulfonamides

Acetazolamide, Acetazolamide Sodium (Diamox, Dazamide)

Carbonic Anhydrase Inhibitor Diuretic; Antiglaucoma Agent Highlights Of Prescribing Information • Used primarily for metabolic alkalosis or glaucoma in small animals; HYPP in horses • Contraindicated in patients with significant hepatic, renal, pulmonary or adrenocortical insufficiency, hyponatremia, hypokalemia, hyperchloremic acidosis or electrolyte imbalance • Give oral doses with food if GI upset occurs • Electrolytes… Read More »

Algorithm For Emergency Treatment Of Hemorrhage In The Broodmare

A simplified, step-by-step, sample flow chart for hemorrhage treatment is outlined below. The clinician should keep in mind that this outline describes an attempt to treat what should be a surgical problem, medically. One can only surmise at the nature of the internal insult. Periodic evaluation of the mare without quantification of the severity of… Read More »

Folliculitis: Staphylococcal Pyoderma, Dermatophilosis, and Dermatophytosis

Folliculitis is a common skin disease in the horse. It can be caused by a number of etiologies — including infections with bacteria (Staphylococcus, Streptococcus or Dermatophilus), fungi (dermatophytes), and parasites (Demodex), or by autoimmune diseases (pemphigus foliaceus). Folliculitis is an inflammation of the hair follicle with accumulation of inflammatory cells within the lumen of… Read More »

Cutaneous Adverse Drug Reactions

An adverse drug reaction () is as an undesirable effect that results from the administration of a drug. These reactions can be either immunologic or nonimmunologic. Mechanisms of immunologic adverse drug reactions include IgE-dependent mast cell degranulation (type I), antibody mediated cellular cytotoxicity (type II), deposition of immune complexes with initiation of the complement cascade… Read More »

Hepatic Lipidosis And Acute Hepatitis

1. What is hepatic lipidosis? Hepatic lipidosis is a common disease of cats in which excessive fat accumulates in hepatocytes and may lead to severe intrahepatic cholestasis and progressive liver failure. Most cases in cats are idiopathic. Diabetes mellitus, pancreatitis, cholangiohepatitis, hyperthyroidism, hypertrophic cardiomyopathy, renal disease, chronic cystitis, chronic upper respiratory infections, hyperadrenocorticism, and neoplasia… Read More »

Acute Pancreatitis

1. Compare acute and chronic pancreatitis. Acute Chronic Acute inflammatory condition Long-standing inflammation No evidence of fibrosis Fibrosis and loss of acinar cell mass Mild or severe Mild or severe Reversible histopathologic changes Irreversible histopathologic changes   2. Describe the pathophysiology of severe pancreatitis. Severe pancreatitis is characterized by extensive pancreatic necrosis and multiple organ… Read More »

CHLORPROPAMIDE

Chemistry An oral sulfonylurea antidiabetic agent, chlorpropamide occurs as a white, crystalline powder having a slight odor. It is practically insoluble in water. Storage – Stability – Compatibility Chlorpropamide tablets should be stored in well-closed containers at room temperature. Pharmacology Sulfonylureas lower blood glucose concentrations in both diabetic and non-diabetics. The exact mechanism of action… Read More »

CHLOROTHIAZIDE

CHLOROTHIAZIDE SODIUM Chemistry A thiazide diuretic structurally related to the sulfonamides, chlorothiazide occurs as a white or practically white, odorless, slightly bitter-tasting, crystalline powder. It has a melting point of approximately 355° C and pKas of 6.7 and 9.5. It is very slightly soluble in water and slightly soluble in alcohol. The pH of the… Read More »

Antiseptics

Agents which inhibit the growth of microorganisms, and are suitable for application to wounds or the unbroken skin. Preparations designed to kill organisms are properly called ‘disinfectants’ or ‘germicides’. Many substances may be either antiseptic or disinfectant according to the strength used. Very strong antiseptic or disinfectant solutions should not be used for wounds because… Read More »

ETODOLAC

Chemistry – Storage – Stability – Compatibility An indole acetic acid derivative non-steroidal antiinflammatory agent (NSAID), etodolac occurs as a white, crystalline compound that is insoluble in water, but soluble in alcohol or DMSO. The commercially available veterinary tablets should be stored at controlled room temperature (15-30°C). Pharmacology Like other NSAIDs, etodolac has analgesic, antiinflammatory… Read More »