Tag Archives: Tobramycin

Diseases of the Ear: General Principles Of Management

The therapeutic plan for otitis externa requires identification of the primary disease process and perpetuating factors. Ideally management is aimed at thoroughly cleaning and drying the ear canal, removing or managing the primary factors, controlling perpetuating factors, administering appropriate topical or systemic therapy (or both), and evaluating response to therapy. Ear Cleaning Ear cleaning serves… Read More »

Therapy For Specific Diseases Of The External Ear Canal

Ectoparasites Thorough cleaning of the external ear canal, treatment of all household pets, and whole-body therapy should be considered in the treatment regimen for ear mites. Pets with no clinical signs may be asymptomatic carriers and a reservoir for reinfestation. Otic parasiticides such as pyrethrins, rotenone, amitraz, and carbaryl must be administered every 24 hours… Read More »

Diseases Of The Middle And Inner Ear

Normal Anatomy and Physiology The middle ear consists of the tympanic membrane, three cavities (epitympanic, tympanic, and ventral), and the bony ossicles (malleus, incus, and stapes). The tympanic membrane has two parts: (1) the thin pars tensa that attaches to the manubrium of the malleus and (2), above the pars tensa, the thicker, pars flaccida.… Read More »

Amikacin Sulfate (Amikin, Amiglyde-V)

Aminoglycoside Antibiotic Highlights Of Prescribing Information • Parenteral aminoglycoside antibiotic that has good activity against a variety of bacteria, predominantly gram-negative aerobic bacilli • Adverse Effects: Nephrotoxicity, ototoxicity, neuromuscu-lar blockade • Cats may be more sensitive to toxic effects • Risk factors for toxicity: Preexisting renal disease, age (both neonatal & geriatric), fever, sepsis &… Read More »

Antibacterial preparations

Bacterial infections of the eye in animals may be caused by Staphylococcus, Streptococcus, Bacillus, Actinobacillus, Chlamydophila (Chlamydia), Moraxella, Micrococcus, or Clostridium spp. This list is not exhaustive and the bacteria involved vary between species. Ocular infections usually present as conjunctivitis, blepharitis, keratitis, keratocon-junctivitis, or uveitis. The aminoglycosides gentamicin, tobramycin and framycetin have a broad-spectrum bactericidal… Read More »

Aminoglycosides

This group includes streptomycin, dihydrostreptomycin, neomycin, framycetin, gentamicin, paromomycin, amikacin, tobramycin, and apramycin. All are bactericidal and active against Gram-negative organisms and some Gram-positive organisms, but not streptococci. Amikacin, gentamicin, and tobramycin are active against Pseudomonas aeruginosa. Aminoglycosides are taken up into bacteria by an oxygen-dependent process and are therefore inactive against anaerobic bacteria. They… Read More »