Dog Breed Predisposition to Conditions, Diseases and Disorders

Cardiovascular conditions

Aortic stenosis

• Congenital

• Relative risk 5.4

• No sex predilection

• Mode of inheritance is possibly autosomal dominant with modifying genes, or polygenic

Dermatological conditions

Follicular lipidosis of Rottweilers

• Suspected genetic predisposition

• Affects young dogs of either sex

Follicular parakeratosis

• Females predisposed

• Possible X-linked mode of inheritance

Muzzle folliculitis/furunculosis

• Also known as canine acne

• Local trauma, hormones and genetics may play a role in the pathogenesis

Mucocutaneous hypopigmentation

• Congenital in this breed; affects lips and nose

Hypopigmentary disorders

• Possibly inherited


• Presumed to be hereditary

Onychodystrophy Vasculitis

• Uncommon

• Usually type III hypersensitivity reaction

Skin tumours

• See under Neoplastic conditions

Gastrointestinal conditions

Parvovirus enteritis

• Breed predisposition

• Usually young dogs

• See also under Immunological conditions

Eosinophilic gastroenteritis, enteritis and enterocolitis

• Breed predisposition

• Most common in dogs 5 years and younger

Gastrointestinal eosinophilic granuloma

• Possible breed predisposition

• Most common in young to middle-aged dogs

Lobular dissecting hepatitis

• Possible breed predisposition

• Seen primarily in young dogs (7 months or younger)

• Females may be predisposed

Immunological conditions

Susceptibility to parvovirus

• This breed susceptible to severe and often fatal parvovirus infection

• Resistance to other diseases usually normal


• Several related Rottweilers showed multiple immunological defects

• Inheritance suspected

Infectious conditions

Parvovirus enteritis

• Breed predisposition

• See also under Immunological conditions

Infectious skin disease

• See under Dermatological conditions

Musculoskeletal conditions

Elbow dysplasia

• Also known as osteochondrosis

• Genetically determined in this breed

• Medial coronoid process disease is common in this breed


• Idiopathic

• Affects dogs from 6-9 months old

Plasmacytic-lymphocytic gonitis

• Aetiology unknown

• Observed in less than 10% of dogs undergoing cruciate surgery

Chronic sesamoiditis

• Present in 44% of Rottweilers in one study

• Not necessarily associated with lameness

Juvenile onset distal myopathy

• Uncommon

Hock osteochondrosis

• Common disease

• Affects the proximal medial and lateral trochlear ridges in this breed

Cranial cruciate ligament rupture

• Common cause of hind-limb lameness

• Neutered individuals may be predisposed

• Young animals may be predisposed in this breed

Hip dysplasia

• A large 1989 study showed a prevalence of 24.6% in this breed


• Reported to be familial in this breed

• See also under Neoplastic conditions

Neoplastic conditions

Squamous cell carcinoma of the digit

• Possible breed predisposition

• Older dogs

• Dogs with black coats seem to be more frequently affected

Canine cutaneous histiocytoma

• Possible breed predisposition

• More common in young dogs 1-2 years of age

Primary bone tumours (most commonly osteosarcoma)

• Breed predisposition

• Males may be predisposed

Neurological conditions

Congenital deafness

• Signs seen from birth

Spinal muscular atrophy

• Inheritance suspected

• Rare; has been reported in this breed

• Age of clinical onset: 4 weeks

Atlantoaxial subluxation

• Congenital

• Seen occasionally in this breed

• Age of clinical onset: < 1 year

Meningitis and polyarteritis

• Reported in this breed

• Age of onset: < 1 year

Neuroaxonal dystrophy

• Autosomal recessive inheritance suspected

• Rare

• Age of clinical onset: < 1 year

Rottweiler distal sensorimotor polyneuropathy

• Reported in the USA

• Age of clinical onset: > 1 year

Leukoencephalomyelopathy of Rottweilers

• Autosomal recessive inheritance suspected

• Occasionally seen in the USA, UK, Netherlands and Australia

• Age of clinical onset: 1.5-4 years

Ocular conditions

Entropion (usually lateral lower lids)

• Breed predisposition; polygenic inheritance likely


• Breed predisposition; mode of inheritance unclear

Medial canthal pocket syndrome

• Breed predisposition resulting from head shape

Refractory corneal ulceration

• Breed predisposition

• Age of onset: 5-10 years

Persistent pupillary membranes

• Breed predisposition

• Schedule 3 of the BVA/KC/ISDS Eye Scheme

Iris cyst

• Breed predisposition

Iris coloboma

• Congenital; reported in this breed

• May be seen with other ocular defects


• Inheritance suspected

• Localisation: posterior polar subcapsular cataract

• Age of onset: <2 years; slow progression

Multifocal retinal dysplasia

• Congenital condition autosomal recessive inheritance suspected

• Schedule 1 of the BVA/KC/ISDS Eye Scheme

Generalised progressive retinal atrophy (GPRA)

• Mode of inheritance unknown but presumed recessive

• Seen as an advanced condition at 3 years

Retinal detachment

• Inheritance suspected

• Seen at 2-3 years of age

• May be associated with vitreal abnormalities

Multiple ocular defects

• Inheritance suspected

• Defects may include microphthalmia, congenital cataract and retinal dysplasia

• Schedule 3 of the BVA/KC/ISDS Eye Scheme

Physiological conditions

Additional process on the medial aspect of the central tarsal bone

Lateral tarsal torsion and tarsal valgus deformity

• Unknown aetiology

• Cosmetic fault

Blood group

• Tend to be DEA 1.1 or 1.2 positive

Renal and urinary conditions

Familial renal disease

• Chronic renal failure has been reported in four related dogs aged 6-12 months

• Primary glomerular disease was diagnosed

Sphincter mechanism incompetence

• Possible breed predisposition in female dogs

Reproductive conditions

Variation in the interoestrus interval

• Fertile cycles may occur as often as every 4.5 months in this breed