Anticancer Action by Urogenital System

Kidney Cancer

Black Cumin (Nigella Sativa): This herb provides a chemopreventive effect against induced renal carcinogenesis. Treatment of rats orally with black cumin (50 and 100 mg/kg body weight) resulted in significant decreases in blood urea nitrogen and serum creatinine, as well as in the incidence of tumors.

Mistletoe (Viscum Album): Extracts of mistletoe plant have been used for decades in cancer therapy for nonspecific stimulation of the immune system. Mistletoe lectin has been identified as the active principle with cytotoxic and immunomodulatory potencies. An aqueous mistletoe extract was investigated in renal cell carcinoma, colon carcinoma, and testicular carcinoma. After induction of these tumors, mice were treated with the extract at dose levels corresponding to 0, 0.3, 3, 30, or 300ngmL/kg/d by the intraperitoneal or subcutaneous route for 4 consecutive weeks. Significant tumor growth inhibition was observed with these carcinomas at 30 and 300ngmL/kg/d (Burger, 2001).

Astragalus (Astragalus Membranaceus) And Cnidium (Ligustrum Lucidum): Renal cell carcinomas were planted in mice. One group was treated intraperitoneally daily for 10 days with 100 microliters of phytochemicals that contained 500 micrograms each of Astragalus membranaceus and Ligustrum lucidum; the other group (controls) received saline. A “cure rate” of 57% was obtained with these phytochemicals, which may have exerted their antitumor effects via augmentation of phagocyte and lymphokine-activated killer (LAK) cell activities.

Bladder Cancer

Kava (Piper Methysticum): Flavokawains identified in kava cause strong antiproliferative and apoptotic effects in human bladder cancer cells. The anticarcinogenic effects of flavokawain A were evident in the inhibitory growth (57% inhibition) of bladder tumor cells in a nude mouse model.

Garlic (Allium Sativum): Allium sativum was investigated in induced transitional cell carcinoma in mice. Orally administered Allium sativum was tested at doses of 5mg, 50 mg, and 500mg per 100mL of drinking water. Mice that received 50mg/dl oral Allium sativum demonstrated significant reductions in tumor volume when compared with controls, and mice that received 500mg/dl oral Allium sativum exhibited significant reductions in both tumor volume and mortality.

Prostate Cancer

Saint John’s Wort (Hypericum perforatum): The antiproliferative effects of serotonin reuptake inhibitors and serotonin antagonists have been demonstrated in prostate tumors. Because Saint John’s Wort components act as serotonin reuptake inhibitors and exert cytotoxic effects on several human cancer cell lines, the effects of treatment with Saint John’s Wort extract on the growth of human prostate cancer cells in vitro and in vivo were examined. This study highlighted a significant reduction in tumor growth and in the number of metastases, suggesting that Saint John’s Wort may be useful in the treatment of patients with prostate cancer.

Milk Thistle (Silybum marianum)

Red Clover (Trifolium pratense)